The Anti-Inflammatory Effect of Trichilia martiana C. DC. in the Lipopolysaccharide-Stimulated Inflammatory Response in Macrophages and Airway Epithelial Cells and in LPS-Challenged Mice
MouseEndotoxin/LPSC57BL/6NMalen = 24 mice in total across four groupsOral gavage10 mg/kgGiven on two consecutive days before lipopolysaccharide challenge, with the fin…
Model: Intranasal lipopolysaccharide (10 microgram in 40 microlitre PBS) induced acute lung injury
TMEE reduced bronchoalveolar lavage macrophage numbers by 31.2 per cent and TNF-alpha by 46.91 per cent, comparable with dexamethasone (38.5 and 49.87 per cent), and downregulated ERK, JNK and IkappaB-alpha activation while upregulating lung HO-1. p38 activation was not notably affected.
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