Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice
MouseBurnContact / flameBALB/cMalen = 120 male mice in total; n = 6 per group per time point, n =…Subdermal silastic implant (systemic)Approximately 10 mg crystalline dihydrotestosterone in a 1…Implanted on the same day as burn injury, before wounding
Model: Major contact burn injury, 4 cm2 hot brass rod (approximately 10 per cent total body surface area), with wound debridement at 48 h
Dihydrotestosterone accelerated wound closure (30.5 per cent healed by day 7 versus 7.1 per cent in controls), increased basal keratinocyte proliferation and collagen deposition, better maintained body weight and lean mass, lowered day 3 corticosterone, and produced an earlier peak and faster resol…
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