A Potential Role for Excess Tissue Iron in Development of Cardiovascular Delayed Effects of Acute Radiation Exposure
MouseRadiationC57BL/6Male and female (50/50), male only for the time course and ferrostatin experimentsDeferiprone oral in drinking water ad libitum; ferrostatin-1 intraperitonealDeferiprone 2.5 g/litre in acidified drinking water, estima…Both agents started approximately 24 h before irradiation
Model: Single uniform total body gamma irradiation of 8.53 Gy (LD50/30) from a caesium source, haematopoietic acute radiation syndrome model
Serum iron and transferrin saturation peaked at 2 weeks post irradiation and normalised by 4 weeks, myocardial iron appeared by 2 weeks and persisted to 12 weeks, and coronary endothelial cell density fell from 2 weeks and remained reduced to 12 weeks. Deferiprone pretreatment reduced myocardial ir…
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