The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 32 rats in total, 8 per group across four groupsIntraperitoneal50 mg/kg per the abstract; the methods section states 100 m…Pretreatment beginning five days before ischaemia
Model: Ruptured abdominal aortic aneurysm model: controlled haemorrhagic shock to mean arterial pressure of 50 mmHg or less for 60 min, then infrarenal aortic and iliac clamping for 60 min of ischaemia with resuscitation, followed by reperfusion, assessing renal injury
Whortleberry treatment lowered renal malondialdehyde and raised glutathione relative to the ischaemia-reperfusion group, reduced tubular necrosis scores (median 2.00 versus 8.00) and markedly lowered caspase-3 positivity (1.00 versus 3.50), indicating protection against ischaemia-reperfusion relate…
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