Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-Dawleymaleintravenouscommenced 24 h after surgery
Model: Transient occlusion of the left middle cerebral artery (acute ischaemic stroke)
Intravenous IGF-1 raised IGF-1 levels in plasma, ischaemic amygdala, hippocampus and cortex, improved neurological dysfunction and cognitive deficits, reduced cerebral infarction and brain oedema, lowered serum and hippocampal IL-6, IL-1 beta and TNF-alpha, and attenuated hippocampal tau phosphoryl…
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