Bradykinin-Potentiating Activity of a Gamma-Irradiated Bioactive Fraction Isolated from Scorpion (Leiurus quinquestriatus) Venom in Rats with Doxorubicin-Induced Acute Cardiotoxicity: Favorable Modulation of Oxidative Stress and Inflammatory, Fibrogenic and Apoptotic Pathways.
RatChemical/toxinWistarmaleintraperitoneal1 microgram per gram body weightPretreatment for 3 weeks before doxorubicin; final fraction dose 1 h before dox…
Model: Doxorubicin-induced acute cardiotoxicity (doxorubicin 15 mg/kg intraperitoneally on day 21)
Both fractions attenuated doxorubicin-induced ECG changes, biomarker derangements and histological cardiac injury, with the gamma-irradiated fraction restoring biomarkers to normal levels and outperforming the native fraction.
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