MDM2 inhibition improves cisplatin-induced renal injury in mice via inactivation of Notch/hes1 signaling pathway.
MouseChemical/toxinC57BL/6male
Model: Cisplatin-induced acute renal injury by intraperitoneal injection
Cisplatin raised creatinine, blood urea nitrogen, urinary cystatin C, NGAL and albumin-to-creatinine ratio, lowered glomerular filtration rate and increased tubular injury scores, MDM2, N1ICD, Hes1 and cleaved caspase-3 with a fall in the Bcl-2/Bax ratio. MDM2 inhibition improved these cisplatin-in…
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