Short-term doxorubicin cardiotoxic effects: involvement of cardiac Thyrotropin Releasing Hormone system.

Short-term doxorubicin cardiotoxic effects: involvement of cardiac Thyrotropin Releasing Hormone system.

Model: Single intraperitoneal doxorubicin injection (10 mg/kg/day) producing acute cardiotoxicity

A single doxorubicin injection induced TRH overexpression in the left ventricle, associated with apoptosis, hypertrophy and fibrosis. siRNA-mediated suppression of cardiac TRH prevented the doxorubicin-associated cardiac histological lesions, indicating that doxorubicin requires an active cardiac T…

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