Tissue Plasminogen Activator Loaded PCL Nanofibrous Scaffold Promoted Nerve Regeneration After Sciatic Nerve Transection in Male Rats.
RatOthermalen = 24 mature male rats, divided into four groups (control, axo…implanted scaffold at the transection siteat the time of surgical repair
Model: Sciatic nerve transection (axotomy)
Stereological parameters, GFAP immunohistochemistry and S100, NGF and BDNF gene expression were significantly higher in the tPA-loaded scaffold group than in the axotomy group, with results closest to those of the control group, indicating good functional nerve tissue regeneration over a short peri…
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