Biochemical Evaluation of the Antioxidant Effects of Hydroxytyrosol on Pancreatitis-Associated Gut Injury.
MouseChemical/toxinCD1femalen = 30 mice randomly divided into groups; per-group numbers not…5 mg/kgfirst dose 30 min after the first caerulein injection
Model: Caerulein-induced acute pancreatitis with associated colonic injury; caerulein 50 microgram/kg intraperitoneally hourly for 10 h
Hydroxytyrosol 5 mg/kg reduced serum amylase and lipase, serum and tissue IL-1 beta, IL-6 and TNF-alpha and MCP1/CCL2, lowered histological damage scores in pancreas and colon, reduced mast cell recruitment, intrapancreatic trypsin activity, pancreatic oedema and myeloperoxidase activity, and reduc…
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