Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway.
MouseChemical/toxinC57BL/6J, including miR-382 knockout miceMalen = n = 6 per group at days 1, 3, 7, 14 and 28Intraperitoneal10 mg/kg anti-miR-382First dose within 30 minutes before aristolochic acid injection
Model: Aristolochic acid I nephropathy, single intraperitoneal dose of 10 or 20 mg/kg
Aristolochic acid caused dose- and time-dependent renal fibrosis through NF-kappaB-driven miR-382 upregulation, and miR-382 knockdown or knockout partially reversed tubulointerstitial fibrosis and inflammation.
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