XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia-reperfusion injury.
MouseIschaemia-reperfusionRenalC57BL/6MaleIntraperitoneal10 mg/kg30 minutes before ischaemia, then daily for 3 days after surgery
Model: Unilateral renal ischaemia-reperfusion injury with 30 minutes of renal artery clamping
XJB-5-131 attenuated ischaemia-reperfusion renal injury and inflammation by inhibiting ferroptosis rather than necroptosis or pyroptosis.
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