PRECLINICAL PUBLICATION · 2020

Mitigation of Microglia-mediated Acute Neuroinflammation and Tissue Damage by Heme Oxygenase 1 in a Rat Spinal Cord Injury Model.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

HO-1-overexpressing microglia delivered by adoptive transfer

PMID 32795555 ↗2020Reported benefit

Mitigation of Microglia-mediated Acute Neuroinflammation and Tissue Damage by Heme Oxygenase 1 in a Rat Spinal Cord Injury Model.

RatSpinal cord injuryUnspecifiedSprague-Dawley

Model: Rat spinal cord injury with adoptive transfer of lentivirus-transduced microglia

Adoptive transfer of HO-1-overexpressing microglia suppressed post-injury neuroinflammation, reduced tissue damage and neuronal apoptosis, and moderately improved locomotor function.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.