Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects.
MouseOtherNrf2-null and wild-type C57BL/6JMale and femaleIntraperitoneal40 mg/kg in corn oil; vehicle corn oil 10 mL/kgPre-treatment for 4 days before hyperoxia exposure
Model: Hyperoxia-induced acute lung injury, 95 to 100 per cent oxygen for 68 hours
Beta-naphthoflavone pre-treatment improved survival and reduced hyperoxic lung injury in Nrf2-null and wild-type mice, eliminating the sex difference in survival.
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