Temporary blockade of interferon-gamma ameliorates doxorubicin-induced cardiotoxicity without influencing the anti-tumor effect.
MouseChemical/toxinBALB/c and C57BL/6FemaleGiven simultaneously with repeated doxorubicin dosing, or as a single late inje…
Model: Doxorubicin-induced chronic cardiotoxicity in tumour-bearing and tumour-free mice
Simultaneous or late anti-interferon-gamma antibody treatment preserved cardiac function after doxorubicin without impairing tumour suppression or the main cellular immune response.
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