Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway.
RatEndotoxin/LPSSprague-DawleyMalen = 30 ratsLocal application as direct pulp cappingGelatin sponge soaked in conditioned medium diluted 50 per…Applied immediately after pulp exposure and haemostasis
Model: Pulpitis induced by drilling the occlusal surface of the maxillary first molar with coronal pulp exposure and LPS challenge
Dental follicle stem cell conditioned medium reduced inflammatory infiltration and induced Runx2 expression in odontoblast-like cells near the injury site relative to LPS alone.
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