Mithramycin selectively attenuates DNA-damage-induced neuronal cell death.
MouseTBIControlled cortical impactC57BL/6Malen = 7 injury plus vehicle and 8 injury plus mithramycinIntracerebroventricular injection0.3 mM in artificial cerebrospinal fluid, 5 microlitres, ab…Immediately after injury
Model: Moderate controlled cortical impact over the left parietal cortex at 6 m/s with 2 mm deformation depth, plus rat primary neuron cultures
Mithramycin was strongly neuroprotective against DNA-damage-dependent neuronal death in vitro, but after controlled cortical impact it reduced fodrin cleavage and phospho-c-Jun only, with markers of p53-dependent apoptosis showing non-significant trends.
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