Effects of Electrospun Fibrous Membranes of PolyCaprolactone and Chitosan/Poly(Ethylene Oxide) on Mouse Acute Skin Lesions.
MouseWoundC57BL/6Malen = 64 mice divided into two groupsTopical, sutured in placeOne membrane sutured over the wound, hydrated daily with 0.…Applied immediately after wound creation
Model: Full-thickness 1 cm2 dorsal excisional skin wound down to the muscular fascia
The chitosan and poly(ethylene oxide) coated membrane increased wound healing rate on days 3, 6 and 9 and raised inflammatory infiltrate, PCNA, alpha-SMA, TNF-alpha and MCP-1 relative to polycaprolactone alone.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.