The effects of human prothrombin complex concentrate on hemorrhagic shock-induced lung injury in rats: Implications for testing human blood products in rodents.
RatHaemorrhage/shockControlledSprague-Dawleymale20 IU/kg or 50 IU/kg added to Lactated Ringer's solutionAt resuscitation, after 60 minutes of controlled haemorrhage
Model: Splenic injury with controlled haemorrhage for 60 minutes followed by resuscitation
Prothrombin complex concentrate at 20 or 50 IU/kg did not reduce haemorrhagic shock-induced pulmonary vascular permeability in rats, although it modestly increased clotting potential; only rat fresh frozen plasma reduced pulmonary leak, suggesting a xenogenic species effect.
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