Duraplasty of PHBV/PLA/Col membranes promotes axonal regeneration by inhibiting NLRP3 complex and M1 macrophage polarization in rats with spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyfemaleSurgical implantation as a dural substitute (duraplasty) at the lesion siteAt the time of injury, during durotomy performed after contusion
Model: Contusion spinal cord injury at T10 followed by durotomy and duraplasty
Duraplasty with PHBV/PLA/Col membranes reduced inflammasome activation and CD86-positive macrophage infiltration, decreased glial scar formation, increased NF-200 expression and improved locomotor recovery at 8 weeks after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.