Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis.
RatChemical/toxinSprague-DawleyFemale (pregnant)Intraperitoneal30 minutes before model establishment (pretreatment)
Model: Acute pancreatitis in pregnancy induced by retrograde injection of sodium taurocholate
Thyroid injury occurred in acute pancreatitis in pregnancy and was attenuated by ISO-1 pretreatment, which reduced MIF expression, attenuated CD68, CD3 and ICAM-1 activation and improved oxidative stress status in maternal thyroid tissue.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.