Homing of Adipose-Derived Stem Cells to a Tendon-Derived Hydrogel: A Potential Mechanism for Improved Tendon-Bone Interface and Tendon Healing.
RatWoundLocal hydrogel application to the injury site or subcutaneous injection; labelled adipose-derived stem cells by tail vein injectionHydrogel or saline at the time of injury; labelled stem cells by tail vein 1 we…
Model: Acute tendon injury and chronic tendon-bone interface injury models, plus a subcutaneous injection model
Systemically delivered adipose-derived stem cells homed to acute tendon and chronic tendon-bone interface injuries and to the tendon-derived hydrogel, but there was no difference in macrophage number, cell proliferation or angiogenesis one week after delivery.
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