Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6J and Nrf2 knockout mice on the same genetic backgroundn = 60 C57BL/6J and 48 Nrf2 knockout mice; n = 6 per group acro…Tail vein injectionFerrostatin-1 1.5 mg/kg; Fe-citrate(III) 15 mg/kg; in vitro…Pre-treatment, prior to blocking the superior mesenteric artery
Model: Intestinal ischaemia-reperfusion induced acute lung injury by clipping the superior mesenteric artery for 45 min followed by 180 min reperfusion
Ferrostatin-1 pre-treatment ameliorated lung pathological injury, pulmonary oedema, lipid peroxidation and cell death whereas iron aggravated them, and Nrf2 inhibited ferroptosis by promoting SLC7A11 and HO-1 expression.
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