Rosamultin Attenuates Acute Hypobaric Hypoxia-Induced Bone Injuries by Regulation of Sclerostin and Its Downstream Signals.
RatOtherPretreatment before hypobaric hypoxia exposure
Model: Acute hypobaric hypoxia simulating high altitude, causing bone damage and abnormal bone remodelling
Rosamultin pretreatment reduced hypobaric hypoxia induced oxidative stress and inflammation, improved bone metabolic abnormalities and rebalanced bone remodelling by suppressing sclerostin and activating Wnt/beta-catenin signalling.
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