Evaluation of a new collagen-based medical device (ElastiCo) for the treatment of acute Achilles tendon injury and prevention of peritendinous adhesions: An in vitro biocompatibility and in vivo investigation.
RatOtherSprague-DawleyMalen = 28 rats, both Achilles tendons operatedLocal implantation, scaffold film wrapped around the sutured tendonAt the time of surgical repair
Model: Surgically induced acute lesion of both Achilles tendons, repaired by suture
At 8 and 16 weeks the collagen scaffold reduced internal and external peritendinous adhesions and collagen III content and increased collagen I; elastic modulus increased over time with both treatments.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.