Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats.
RatSpinal cord injuryCompressionWistarFemaleIntravenousAcutely, or at 3 h or 24 h post-injury
Model: Thoracic clip impact-compression spinal cord injury
Acute and 3 h delayed intravenous elezanumab improved locomotion, fine motor function and gait, reduced lesion area, increased neuronal sparing and axonal plasticity, and produced earlier spontaneous voiding with less bladder wall hypertrophy; the 24 h group trended better with significantly greate…
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