3,6'-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation.
RatTBIControlled cortical impactSprague-DawleyMalen = n = 5 per group for contusion volume, behaviour, Fluoro-Jad…IntravenousDP 0.1 and 0.5 mg/kg; pomalidomide 0.1 and 0.5 mg/kg5 h post-injury (primary); a 7 h post-injury arm was also tested and was ineffe…
Model: Moderate controlled cortical impact, 5 mm craniotomy over left parietal cortex, 5 mm rounded tip at 4 m/s to 2 mm below dura
A single intravenous dose at 5 h post-injury reduced contusion volume from 19.0 +/- 0.74 per cent (vehicle) to 12.9 +/- 0.22 and 7.4 +/- 0.87 per cent with DP 0.1 and 0.5 mg/kg, improved all four behavioural tests, preserved NeuN positive neurons, reduced degenerating neurons by 64.9 to 65.6 per ce…
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