Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.
MouseRadiationC57BL/6Male and femaleIntraperitoneal injection, compound dissolved in 0.1 mL of 40% (2-hydroxypropyl)-beta-cyclodextrinImmediately before irradiation
Model: Whole-body gamma irradiation at 8 Gy
A single dose of NSC194598 given immediately before 8 Gy gamma irradiation increased survival; the compound inhibited p53 DNA binding and target gene induction when p53 was stabilised by irradiation or chemotherapy.
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