Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis.
MouseChemical/toxinC57BL/6Intravenous (tail vein in mice, intravenous infusion in monkeys)Biodistribution used 5 x 10^6 DiR-labelled cells in 200 mic…
Model: Bleomycin-induced lung injury and pulmonary fibrosis (1.5 mg/kg bleomycin sulfate intratracheally)
Intravenous IMRCs inhibited pulmonary inflammation and fibrosis and improved survival in a dose-dependent manner, outperforming umbilical cord MSCs and pirfenidone, with an acceptable safety profile in mice and monkeys.
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