Effects of adenosine triphosphate on methanol-induced experimental optic nerve damage in rats: biochemical and histopathological evaluation.
RatChemical/toxinWistar albinoMalen = 18 rats total, 6 per groupIntraperitoneal injection (the article title and conclusion describe the route as intravenous)4 mg/kg4 hours after methanol administration
Model: Oral 20% methanol at 3 g/kg producing toxic optic neuropathy
ATP normalised oxidative stress parameters and prevented the increase in optic nerve thickness, astrocyte number and oedema-vacuolisation seen after methanol, with no significant difference from healthy controls.
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