Therapeutic effects of mangiferin on sepsis-associated acute lung and kidney injuries via the downregulation of vascular permeability and protection of inflammatory and oxidative damages.
MouseEndotoxin/LPSn = 8 per groupOral administration20, 50 and 100 mg/kgOnce daily for 7 days before LPS injection
Model: Lipopolysaccharide-induced sepsis (1 mg/kg body weight by tail vein injection) with acute lung and kidney injury
Mangiferin reduced lung and kidney histopathological injury and capillary albumin permeability, preserved occludin and syndecan-1, inhibited MMP-9, reduced oxidative damage and suppressed NF-kappaB and HMGB1 signalling.
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