PRECLINICAL PUBLICATION · 2020

Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Nobiletin

PMID 32538091 ↗2020Reported benefit

Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes.

MouseChemical/toxinC57BL/6Male10 mg/kgPretreatment before concanavalin A

Model: Concanavalin A-induced acute liver injury

Nobiletin pretreatment lowered ALT and AST, reduced reactive oxygen species and TNF-alpha and interferon-gamma release, promoted hepatocyte proliferation, reduced apoptosis and suppressed JNK signalling.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.