Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury.
MouseTBIBlast / overpressureC57BL/6MaleIntraperitoneal injection10 mg/kg in 100 microlitres of 7% sodium bicarbonate48, 54 and 71 hours after the last blast exposure
Model: Repetitive blast overpressure exposure causing mild traumatic brain injury, compared with single blast
L-NAME given after blast blocked delayed-onset blood-brain barrier disruption, prevented CD4 T-cell infiltration and ICAM-1 increases in cerebellum, and prevented rotarod sensorimotor impairment measured 30 days later, long after drug clearance.
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