Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice.
MouseChemical/toxinC57BL/6MaleOral administration10 mg/kg or 30 mg/kgStarted one week before doxorubicin injection and continued afterwards
Model: Doxorubicin-induced acute cardiac injury, doxorubicin 15 mg/kg in 200 microlitres phosphate-buffered saline intraperitoneally
Asiatic acid attenuated cardiac injury and improved cardiac function after doxorubicin, suppressed myocardial oxidative damage and apoptosis in a dose-dependent manner without affecting cardiac inflammation, and improved cardiomyocyte viability in vitro; protection was lost with AKT inactivation, a…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.