A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1beta signaling interruption.
RatEndotoxin/LPSSprague-DawleyMaleAdministered in either a prophylactic or a curative regimen relative to lipopol…
Model: Lipopolysaccharide-induced acute lung injury and myocarditis
Nifuroxazide improved lung and heart histology and reduced inflammatory infiltration, lowered serum injury biomarkers, improved oxidative status and inhibited TLR4/NLRP3/IL-1beta signalling in both prophylactic and curative regimens.
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