Intravenous administration of human amniotic mesenchymal stem cells improves outcomes in rats with acute traumatic spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntravenous via the tail vein2 hours after injury
Model: Weight-drop contusion acute traumatic spinal cord injury
Intravenous hAMSCs migrated to the lesion, reduced ED1 macrophage/microglia and caspase-3 positive cell numbers and inflammatory cytokines, attenuated Evans blue extravasation, promoted angiogenesis and axonal regeneration and significantly improved functional recovery.
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