Recombinant thrombomodulin protects against LPS-induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx.
MouseEndotoxin/LPSC57BL/6Malen = Survival cohort of 80 control mice reported (52/80 alive at…Intraperitoneal injection30 mg/kg3 and 24 hours after LPS injection
Model: Lipopolysaccharide-induced endotoxaemia and acute respiratory distress syndrome, LPS 20 mg/kg intraperitoneally after 16 hours starvation
rhTM improved survival relative to controls at 48 hours after LPS, lowered serum IL-6 and HMGB1, attenuated pulmonary capillary endothelial glycocalyx injury and preserved glycocalyx synthesis gene and protein expression.
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