A Selective P2Y Purinergic Receptor Agonist 2-MesADP Enhances Locomotor Recovery after Acute Spinal Cord Injury.
MouseSpinal cord injuryCompressionGiven after T9 crush injury, with assessment up to 6 weeks
Model: T9 crush spinal cord injury (acute)
2-MesADP improved limb motor function by 6 weeks after injury with neuronal regeneration and axon remyelination at 2 and 6 weeks, and altered expression of apoptosis, regeneration and myelination genes (Nefh, NeuroD6, Dcx, Mag, Mog, Cnp), with Wnt signalling identified as the most affected pathway.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.