Tetrandrine Attenuated Doxorubicin-Induced Acute Cardiac Injury in Mice.
MouseChemical/toxinC57BL/6JMaleOral50 mg/kg in 0.2 mLStarted one day before doxorubicin injection
Model: Acute cardiac injury induced by a single intraperitoneal injection of doxorubicin 15 mg/kg
Tetrandrine prevented doxorubicin-related whole-body wasting and heart atrophy, lowered markers of cardiac injury, improved cardiac function, and reduced oxidative damage and myocardial apoptosis. It increased Nrf2 expression and activity, and its protection was abolished in Nrf2-deficient mice.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.