Safety and Effectiveness of Copaiba Oleoresin (Ducke) on Inflammation and Tissue Repair of Oral Wounds in Rats.
RatWoundWistar, taken from MeSH indexingMalen = 45 male rats in total, 15 per group across control, cortico…Oral gavage200 mg/kg body weight, 10 per cent of the lowest lethal dos…First dose 12 h after induction of the traumatic ulcer
Model: Traumatic ulcer of the oral mucosa induced with a 3 mm circular biopsy punch on the ventral surface of the tongue, 5 mm from the apex at the midline, to 2 mm depth, under ketamine 90 mg/kg plus xylazine 10 mg/kg intraperitoneally
Copaiba-treated wounds were significantly smaller at day 3 than corticoid-treated (p less than 0.05) and control (p less than 0.01) wounds and had closed by day 7, with all groups closed by day 15. Copaiba gave higher re-epithelialisation scores at days 3 and 7 and better organised collagen at day…
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