Basic fibroblast growth factor and agarose gel promote the ability of immune privilege of allogeneic cartilage transplantation in rats.
RatOtherSprague DawleyMalen = 196 adult male Sprague Dawley rats in total, n = 7 per grou…Local implantation of the agarose gel into the femoral osteochondral defectBasic fibroblast growth factor solution 5 mL at 500 mg/mL a…Gel implanted at the time of defect creation, with allogeneic articular cartila…
Model: Full-thickness osteochondral defect 3.0 mm by 3.0 mm created in the trochlear groove of the distal femur under 10 per cent chloral hydrate anaesthesia at 4 mL/kg, followed by allogeneic or autologous osteochondral cartilage transplantation
At 6 weeks the allogeneic cartilage with agarose gel plus basic fibroblast growth factor group showed smooth integrated graft surfaces of adequate thickness comparable with the autologous group, with International Cartilage Repair Society scores significantly higher than allogeneic cartilage alone…
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