Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.

PMID 32439208 ↗2020Reported benefit

Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.

MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6MaleIntraperitoneal, dissolved in 0.9 per cent normal saline10 microgram/kg body weight in the abstract and peptide met…Administered at the time of reperfusion, after 60 min of ischaemia

Model: Intestinal ischaemia-reperfusion by upper midline laparotomy under isoflurane with vascular clip occlusion of the superior mesenteric artery for 60 min followed by reperfusion, with 1 mL normal saline subcutaneously for resuscitation

M3 reduced ischaemia-reperfusion induced AST by 60.1 per cent (p = 0.03) and ALT by 65.7 per cent (p less than 0.0001), attenuated LDH by 40.7 per cent (p = 0.06) and lactate by 46.6 per cent (p = 0.002), and cut serum IL-6 by 40.9 per cent and TNF-alpha by 77.4 per cent. Intestinal TNF-alpha and M…

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Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.

Evidence by therapy association

Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.