Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-kappaB via activation of SIRT1 in mice.
MouseEndotoxin/LPSC57BL/6Female1 h before LPS administration (pretreatment)
Model: Lipopolysaccharide-induced acute lung injury
Aloin pretreatment reduced inflammatory cell influx, cytokines, oedema, myeloperoxidase activity and lipid peroxidation, restored GSH and SOD, and suppressed NF-kappaB and NLRP3 activation; protection was reversed by SIRT1 inhibition.
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