Inhibition of Rb phosphorylation leads to HS-mediated inhibition of NF-kB in acute pancreatitis and associated lung injury in mice.
MouseChemical/toxinSwissMaleIntraperitonealPalbociclib 25 mg/kg body weight1 h after the first caerulein injection
Model: Caerulein-induced acute pancreatitis with associated lung injury (6 consecutive hourly intraperitoneal injections)
Pharmacological inhibition of CDK4/6 and of hydrogen sulphide production improved pancreatic and lung histopathology, lowered serum amylase, myeloperoxidase activity and TNF-alpha, raised IL-10, and reduced NF-kappaB activation and alpha-SMA expression.
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