PRECLINICAL PUBLICATION · 2020

MiR-124-3p helps to protect against acute respiratory distress syndrome by targeting p65.

Mixed / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

miR-124-3p agomir

PMID 32391561 ↗2020Reported benefit

MiR-124-3p helps to protect against acute respiratory distress syndrome by targeting p65.

MixedEndotoxin/LPSMale

Model: Lipopolysaccharide-induced acute respiratory distress syndrome

miR-124-3p expression fell after LPS exposure; agomir treatment attenuated alveolar haemorrhage and interstitial oedema, reduced IL-1beta, IL-6 and TNF-alpha, and suppressed p65 expression and apoptosis.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.