(E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests.
RatChemical/toxinWistarMalen = Four groupsOral150 microgram/kg body weightPretreatment for 7 days before isoproterenol
Model: Isoproterenol-induced myocardial infarction (85 mg/kg subcutaneously at 24 h intervals on days 6 and 7)
Pretreatment with compound 1c improved the electrocardiogram pattern, significantly reduced cardiac dysfunction markers raised by isoproterenol, and lowered fibrinogen, suggesting an anticoagulant action against thrombosis in acute myocardial infarction.
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