Effect of VX-765 on the transcriptome profile of mice spinal cords with acute injury.
MouseSpinal cord injuryContusionC57BL/6Femalen = 27 mice total; 9 per group; n = 6 per group for western blo…Intraperitoneal100 mg/kg prepared in DMSOImmediately following injury
Model: Contusive thoracic (T9) spinal cord injury using an Infinite Horizon impactor, 1.3 mm rod, 50 Kdynes force, 0 sec dwell time
VX-765 inhibited activation of caspase-1 and caspase-3 in injured spinal cords and produced 1,137 upregulated and 1,762 downregulated differentially expressed genes, with downregulated pathways including focal adhesion, cytokine-cytokine receptor interaction, leukocyte transendothelial migration, E…
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