Myricetin against myocardial injury in rat heat stroke model.
RatOtherSprague-DawleyMaleIntragastric5 to 25 mg/kg body weightGiven for one week before heat stress
Model: Heat stroke induced by exposure of anaesthetised rats to 43 degrees C ambient temperature for 70 min
Chronic myricetin pretreatment upregulated HSP-72 and significantly reduced hyperthermia, hypotension, cardiac inflammatory and oxidative damage and lethality; blocking HSP-72 reversed both the cardioprotection and the survival benefit.
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