Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis.
MouseChemical/toxin
Model: Enteral trinitrobenzene sulfonate (TNBS) induced acute necrotising ileocolitis modelling neonatal necrotising enterocolitis
Platelet activation began around 3 h after TNBS, before mucosal injury or endotoxinaemia, and was driven by thrombin activated by macrophage tissue factor; targeted nanomedicine thrombin inhibition was protective without increasing interstitial haemorrhage.
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