LincRNA-p21 promotes classical macrophage activation in acute respiratory distress syndrome by activating NF-κB.

LincRNA-p21 promotes classical macrophage activation in acute respiratory distress syndrome by activating NF-κB.

Model: Intratracheal instillation of lipopolysaccharide to induce acute respiratory distress syndrome, with parallel LPS-treated alveolar macrophage cultures

LincRNA-p21 was elevated in LPS-induced acute respiratory distress syndrome and in LPS-treated alveolar macrophages. Inhibition of lincRNA-p21 counteracted M1 activation and p65 nuclear translocation and attenuated LPS-induced lung injury.

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